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KMID : 1134820140430101491
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Journal of the Korean Society of Food Science and Nutrition
2014 Volume.43 No. 10 p.1491 ~ p.1499
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Cholesterol Improvement Effects of Co-treatment with Black Raspberry and Red Ginseng Extracts in Mice Fed a High Cholesterol Diet
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Lee Min-Jung
Lee Su-Jung
Choi Hye-Ran
Lee Jung-Hyun
Jeong Jong-Tae
Choi Kyung-Min
Cha Jeong-Dan
Hwang Seung-Mi
Park Jong-Hyuk
Lee Joo-Hee
Lee Tae-Bum
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Abstract
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We examined the effects of unripe black raspberry (UBR) and red ginseng (RG) extracts on cholesterol improvement in C57BL/6J mice fed a HCD (high cholesterol diet) for 12 weeks. Hepatic total lipid and total cholesterol contents were significantly induced in hyperlipidemic mice. However, supplementation with UBR, RG and simvastatin effectively reduced these lipid profiles. Further, UBR and co-treatment with UBR and RG increased expression of LDL receptor, SREBP2, and SR-B1 mRNA compared with HCD. The ApoB/ApoA1 ratio was reduced by co-treatment with UBR and RG compared to treatment with UBR. In addition, histopathologic evaluation showed that co-treatment with UBR and RG suppressed lipid accumulation as well as FAS and leptin expression in plasma. These results indicate that co-treatment with UBR and RG may be useful for the prevention of hypercholesterolemia.
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KEYWORD
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unripe black raspberry, red ginseng, Simvastatin, high cholesterol diet, hypercholesterolemia
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